A, D, G. Glucose tolerance measured as fold changes to the area under the curve (AUC) at the indicated time post-treatment in the 1 yr or 2 yrs old cohort of mice. B, E, H. Insulin levels at the indicated times post-treatment in the 1 yr or 2 yrs old cohort of mice. C, F, I. Homeostatic model assessment scores (HOMA) at the indicated time post-treatment in the 1 yr or 2 yrs old cohort of mice. TA-65 supplemented mice present a better score at 6 months post treatment, indicating a better metabolic rate. J. Oil red O staining of lipid droplets in frozen liver sections from either controls or TA-65 treated mice on a standard diet. Measures were realized post mortem in cancer-free mice. Quantification of Oil Red O area is presented in the right panel (5 images per mice; Photoshop CS3 and Scion Image software were used for image analysis).