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Keratin and proliferation staining in the oral epithelium of dosed K-rasG12 mice. Oral epithelium (lips) were immunostained for cytokeratin 13 (A–D), cytokeratin 6 (E–H), or Ki-67 (I–L) in K-ras+/G12D mice dosed either with vehicle (A, E, I, J) or with 1 mg of tamoxifen (B–D, F–H, K, L) and collected 14 days later. Original magnification: × 25 (B, C, F); × 100 (A); × 200 (I, K); × 400 (A inset, C inset, D, E, G, H, J, L)
