Table 2.

Current therapeutic landscape for myelofibrosis.

Clinical need	Drugs/intervention
Anemia	Corticosteroids Danazol Erythropoietic stimulating agent	Thalidomide Pomalidomide Lenalidomide
Symptomatic splenomegaly	Hydroxyurea Cladibrine, others	Splenectomy
Extramedulary hematopoiesis	Radiation therapy
Risk of thrombosis or recurrence	Low-dose Aspirin	Hydroxyurea
Constitutional symptoms/quality of life	None specifically directed
Risk of leukemia transformation	None specifically directed
Improved survival	Allo stem cell transplantation?