Table 1. Summary of screening tests.
| Coagulation Tests | Normal range | Patienta |
|---|---|---|
| aPTT (sec) | 25.2 – 36.2 | 29.6, 31.9 |
| Prothrombin Time (sec) | 10.1 – 12.6 | 11.9, 12.2 |
| Thrombin Time (sec) | 13.4 – 18.0 | 18.2, 22.6 |
| Reptilase Time (sec) | 15.0 – 19.2 | 21.3 |
| Functional fibrinogen (Clauss, mg/dL) | 208 – 409 | 162 |
| Fibrinogen antigen (mg/dL) | 150 – 375 | 148 |
| Functional fibrinogen (clot weight(55), mg/dL) | 330b | 170 |
| von Willebrand factor antigen (% of normal) | 56 – 223 | 147 |
| von Willebrand factor activity (% of normal) | 50 – 204 | 140 |
| FVIII activity in blood draw 1 (% of normal) | 54 – 161 | 163 |
| FVIII activity in blood draw 2 (% of normal) | 100c | 225 |
| FVIII activity in blood draw 3 (% of normal) | 100c | 225 |
| Antithrombin III (% of normal) | 88 – 133 | 97 |
| PFA-100: collagen and epinephrine (sec) | 84 – 178 | >300, 132d |
| PFA-100: collagen and ADP (sec) | 60 – 107 | 119, 119d |
| Chemistry Tests | ||
| alanine transaminase (U/L) | 15 – 48 | 24, 25, 22 |
| aspartate aminotransferase (U/L) | 14 – 38 | 25, 21, 27 |
| Cholesterol (mg/dL) | 100 – 199 | 220, 251, 192 |
| Triglycerides (mg/dL) | 1 – 149 | 55, 85, 54 |
a
Multiple values are from separate blood draws
b
Fibrinogen concentration in NPP
c
FVIII activity in NPP
d
First PFA-100 was on aspirin, second was off aspirin for 2 weeks