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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Thromb Haemost. 2012 Jul 26;108(3):516–526. doi: 10.1160/TH12-05-0355

Table 3. Thrombin generation parameters in whole and defibrinated plasmas.

Whole Plasmaa Defibrinated Plasmab
NPP Patient NPP Patient NPP plus FVIII
Lag Time (min) 4.4 ± 0.2 4.5 ± 0.2 3.7 ± 0.4 4.0 ± 0.4 3.8 ± 0.6
Time to peak (min) 10.2 ± 0.2 9.4 ± 0.2* 10.4 ± 2.0 9.0 ± 0.3 7.7 ± 0.5
Peak thrombin (nM) 183 ± 16 267 ± 20* 107 ± 27 158 ± 14# 181 ± 45#
ETPc (nM.min) 2052 ± 141 2343 ± 162 1066 ± 216 1244 ± 74 1146 ± 119

Experiments were triggered with 1 pM TF and 4 μM phospholipids.

a

Mean ± standard deviation from three independent experiments from two separate blood draws, performed in triplicate

b

Mean ± standard deviation from two to five independent experiments performed in triplicate

c

ETP, endogenous thrombin potential

*

p<0.05 versus whole NPP

#

p<0.01 versus defibrinated NPP