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. Author manuscript; available in PMC: 2013 Apr 16.
Published in final edited form as: Eur J Pharmacol. 2008 Feb 19;586(0):179–188. doi: 10.1016/j.ejphar.2008.02.035

Figure 2.

Figure 2

Dose-response relationship between acute and chronic heroin doses and jumping frequency. ACUTE (top figure): Mice received a single injection of various heroin doses followed 2 h later by naloxone. CHRONIC (bottom figure): Mice were injected t.i.d. for three days with escalating heroin doses (5, 10, and 20 or 10, 20, and 40 mg/kg on treatment Days 1, 2, and 3, respectively) and a final single heroin dose (40 mg/kg) on Day 4. Withdrawal was precipitated by injecting naloxone (50 mg/kg). Heroin control mice in both treatment paradigms were injected with saline instead of naloxone after injecting the heroin dose eliciting the greatest jumping frequency. Significant differences from control group (**P <0.01) and all other non-control groups (+) are indicated.