Table 2.
Methylation fractions at the IGF2/H19 Imprinted domain by maternal cigarette smoking during pregnancy
| Pregnancy-related smoking behavior | Methylation differences between current smokers and those who |
||||
|---|---|---|---|---|---|
| Smokers (n=75) |
Quit in pregnancy (n=110) |
Never smoked (n=222) |
Quit in pregnancy (p-value) |
Never smoked (p-value) |
|
| H19_CG1 | 59.84 | 60.13 | 59.82 | 0.29 (0.8) | −0.01(1.0) |
| H19_CG2 | 56.81 | 57.50 | 57.58 | 0.68 (0.6) | 0.77 (0.5) |
| H19_CG3 | 59.27 | 60.08 | 59.43 | 0.80 (0.5) | 0.16 (0.9) |
| H19_CG4 | 58.68 | 59.53 | 58.91 | 0.85 (0.5) | 0.23 (0.9) |
| H19 DMR mean | 58.65 | 59.31 | 58.94 | 0.66 (0.6) | 0.29 (0.8) |
|
Smokers (n=63) |
Quit in pregnancy (n=86) |
Never smoked (n=178) |
Quit in pregnancy (p-value) |
Never smoked (p-value) |
|
| IGF2_CG1 | 45.61 | 40.56 | 41.13 | −5.05 (0.0003) | −4.48 (0.001) |
| IGF2_CG2 | 54.17 | 50.74 | 51.44 | −3.43 (0.0006) | −2.73 (0.01) |
| IGF2_CG3 | 53.90 | 49.14 | 49.31 | −4.76 (0.0004) | −4.59 (0.0005) |
| IGF2 DMR mean | 49.50 | 45.86 | 46.64 | −3.63 (0.001) | −2.86 (0.002) |
Means adjusted for maternal education, gestational age, maternal body mass index before pregnancy, race/ethnicity, offspring’s sex, birth weight