TABLE.

Summary of Clinical Severity and Immunohistochemical Findings in Tau^−/− and Wild-Type Mice in Acute Experimental Autoimmune Encephalomyelitis

	Tau−/− Mice	Wild-Type Mice	p
Average CI (days 14–20)	2.4 ± 0.06	1.9 ± 0.05	<0.0001
CD45-positive cells/lesion	15.9 ± 2.7	20.2 ± 3.0	>0.05
Iba1-positive cells/lesion	94.5 ± 14.2	81.8 ± 13.1	>0.05
SMI32-positive axons/lesion	37.0 ± 6.2	22.4 ± 3.0	<0.05
APP-positive axons/lesion	20.3 ± 4.0	8.5 ± 1.0	<0.01

All data are mean ± SEM. Counts were done in 40× fields.

APP, amyloid precursor protein; CI, clinical index.