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Role of transcription factors in cell differentiation along the osteoblast and chondrocyte lineage. Runt-related transcription factor 2 (Runx2) is an essential transcription factor of early osteoblast differentiation as the master gene of bone formation. However, Runx2 is not essential for late stage of osteoblast differentiation and needs to be suppressed for terminal differentiation into osteocytes. Runx2 is also required for chondrocyte maturation.
