Table 2.

Median values (IQR) of plasma pharmacokinetic parameters for fentanyl

Pharmacokinetic parameter	Sublingual fentanyl wafer (n = 11)		Intravenous fentanyl (n = 12)
	Dry mouth (n = 5)	Wet mouth (n = 6)
AUCinf (ng/mL/min), median	16.7 (15.2)	20.4 (19.8)	38.5 (32.4)
AUCt (ng/mL/min), median	NA	15.2 (14.5)	27.7 (20.8)
tfirst (min), median	30 (15)	3.5 (8.8)	NA
Cmax (ng/mL), median	0.11 (0.08)	0.12 (0.11)	0.87 (0.69)
tmax (min), median	67 (60)	61.5 (60)	2 (2)
t1/2 (h), median	NA	4.9 (3.4)	1.7 (1.5)
Bioavailability (%) using AUCinf	NA	53.0	NA

Abbreviations: AUC, area under the concentration-time curve; NA, not applicable; IQR, interquartile range.