Table 2.

Association between SNPs and incidence of pre-menopausal breast cancer and circulating leptin levels among 405 women with breast cancer and 810 women free of breast cancer participation in the Nurses’ Health Study II

Gene	SNP	Minor allele	Major allele	MAF	With breast cancer			With leptin
					N	Odds ratio (95% CI)	P	N	Percentage change per minor allele (%, 95% CI)a	p
LEPR	rs4592284	G	C	0.43	1208	1.04 (0.88–1.23)	0.65	904	1.2 (−5.5, 8.3)	0.74
LEPR	rs4655762	A	G	0.32	1212	1.02 (0.85–1.22)	0.84	907	4.6 (−2.8, 12.6)	0.23
LEPR	rs2148683	G	A	0.47	1209	1.02 (0.86–1.21)	0.80	904	−1.8 (−8.4, 5.3)	0.62
LEPR	rs7540807	C	A	0.1	1215	0.89 (0.67–1.18)	0.43	910	−10.8 (−20.2, −0.3)	0.04b
LEPR	rs913199	A	C	0.45	1213	1.01 (0.86–1.20)	0.89	909	0.5 (−6.1, 7.6)	0.88
LEPR	rs9436729	C	A	0.47	1201	1.01 (0.85–1.19)	0.94	898	0.8 (−6.0, 8.0)	0.83
LEPR	rs17127601	G	A	0.14	1213	0.98 (0.77–1.26)	0.89	908	−6.8 (−15.6, 3.0)	0.17
LEPR	rs3790436	C	G	0.44	1211	1.00 (0.84–1.18)	0.96	906	2.9 (−4.1, 10.3)	0.43
LEPR	rs3806318	G	A	0.25	1206	0.96 (0.79–1.17)	0.72	900	0.6 (−7.1, 8.9)	0.89
LEPR	rs12145690	C	A	0.44	1203	0.97 (0.82–1.15)	0.7	902	2.7 (−4.1, 10.1)	0.44
LEPR	rs4655802	G	A	0.42	1205	1.03 (0.87–1.23)	0.72	901	2.7 (−4.5, 10.4)	0.47
LEPR	rs9436738	A	G	0.13	1214	1.04 (0.82–1.33)	0.74	910	−6.9 (−15.7, 2.9)	0.16
LEPR	rs9436740	A	T	0.28	1206	1.15 (0.95–1.39)	0.17	902	5.7 (−2.3, 14.3)	0.17
LEPR	rs3790433	A	G	0.26	1192	1.06 (0.87–1.28)	0.57	900	−1.9 (−9.2, 6.0)	0.63
LEPR	rs17127618	G	C	0.15	1214	1.02 (0.81–1.28)	0.89	909	3.8 (−5.5, 14.2)	0.44
LEPR	rs9436301	G	A	0.24	1212	1.01 (0.83–1.23)	0.91	907	−4.0 (−11.3, 3.9)	0.31
LEPR	rs9436302c	A	G	0.21	1215	0.97 (0.79–1.20)	0.79	910	−0.2 (−8.2, 8.6)	0.96
LEPR	rs1887285	G	A	0.09	1214	0.95 (0.71–1.26)	0.71	908	−11.5 (−21.2, −0.8)	0.04b
LEPR	rs1045895c	A	G	0.4	1204	0.99 (0.84–1.18)	0.94	905	3.1 (−3.8, 10.5)	0.39
LEPR	rs6657868	A	G	0.38	1212	0.99 (0.83–1.18)	0.90	908	1.6 (−5.3, 9.0)	0.66
LEPR	rs6704167	T	A	0.43	1213	1.01 (0.85–1.19)	0.95	908	−0.1 (−6.6, 6.8)	0.97
LEPR	rs7513047	A	G	0.48	1209	0.97 (0.82–1.16)	0.76	907	1.1 (−5.6, 8.3)	0.75
LEPR	rs11808888	A	G	0.14	1214	1.04 (0.82–1.33)	0.74	910	−6.7 (−15.4, 3.0)	0.17
LEPR	rs6672331	C	G	0.03	1214	0.69 (0.39–1.19)	0.18	910	−3.7 (−21.5, 18.2)	0.72
LEPR	rs11208659	G	A	0.08	1214	1.30 (0.96–1.76)	0.09	909	13.3 (0.3, 28.1)	0.04b
LEPR	rs1627238	A	G	0.17	1210	1.04 (0.83–1.30)	0.75	905	−4.2 (−12.5, 4.9)	0.36
LEPR	rs1171279	A	G	0.25	1213	1.15 (0.94–1.39)	0.17	908	1.5 (−6.3, 10.0)	0.71
LEPR	rs6697315	G	A	0.35	1215	0.98 (0.82–1.18)	0.85	910	2.9 (−4.2, 10.5)	0.44
LEPR	rs10158279	A	C	0.49	1209	1.00 (0.84–1.19)	1	906	0.5 (−6.2, 7.7)	0.88
LEPR	rs1137100c	G	A	0.27	1213	0.86 (0.71–1.05)	0.14	908	0.4 (−7.0, 8.4)	0.92
LEPR	rs3790429	A	T	0.17	1214	1.04 (0.84–1.30)	0.72	908	8.3 (−0.8, 18.1)	0.08
LEPR	rs6588152	A	T	0.21	1215	1.10 (0.90–1.35)	0.36	910	−1.9 (−9.6, 6.5)	0.65
LEPR	rs1137101c	G	A	0.46	1210	0.94 (0.79–1.11)	0.45	905	−1.6 (−8.2, 5.4)	0.64
LEPR	rs4655537	A	G	0.36	1213	1.06 (0.88–1.26)	0.54	909	−1.1 (−7.8, 6.1)	0.75
LEPR	rs3762274	G	A	0.39	1191	0.95 (0.80–1.13)	0.59	891	−2.5 (−9.1, 4.5)	0.47
LEPR	rs11585329	A	C	0.16	1212	0.90 (0.71–1.13)	0.37	907	7.0 (−2.3, 17.1)	0.15
LEPR	rs8179183c	C	G	0.18	1202	1.01 (0.80–1.26)	0.96	896	−0.1 (−8.9, 9.5)	0.98
LEPR	rs6690625	C	A	0.2	1214	0.88 (0.71–1.09)	0.24	909	−1.9 (−9.9, 6.8)	0.66
LEPR	rs10889569	A	T	0.38	1209	0.95 (0.79–1.13)	0.55	904	−1.2(−8.0, 6.0)	0.73
LEPR	rs1805096c	A	G	0.38	1211	0.94 (0.79–1.13)	0.52	906	−0.9 (−7.6, 6.4)	0.81
LEP	rs4731420	C	G	0.18	1212	0.83 (0.67–1.03)	0.1	908	−0.6 (−8.8, 8.3)	0.89
LEP	rs10954172	A	G	0.3	1213	1.02(0.85–1.22)	0.83	909	0.6 (−6.4, 8.1)	0.87
LEP	rs791600	A	G	0.41	1211	1.09 (0.92–1.30)	0.31	906	1.7 (−5.2, 9.0)	0.64
LEP	rs10487506c	A	G	0.44	1214	1.04 (0.88–1.23)	0.62	908	−1.4 (−7.9, 5.4)	0.67
LEP	rs10244329	A	T	0.5	1212	1.02 (0.86–1.21)	0.84	907	1.5 (−5.2, 8.7)	0.67
LEP	rs7795794	A	G	0.07	1215	0.99 (0.70–1.41)	0.96	910	−5.3 (−17.8, 9.2)	0.45
LEP	rs11760956	A	G	0.37	1184	0.99 (0.83–1.19)	0.93	891	3.2 (−3.9, 10.8)	0.39
LEP	rs2071045	G	A	0.24	1213	1.10 (0.90–1.34)	0.34	907	0.0 (−7.8, 8.5)	1.00
LEP	rs4731429	A	G	0.46	1211	0.97 (0.82–1.15)	0.72	906	0.4 (−6.3, 7.5)	0.92
LEP	rs10954176	G	A	0.47	1207	1.00 (0.84–1.18)	0.96	904	−2.3 (−8.8, 4.6)	0.50
					Permutation P = 0.94			Permutation P = 0.67

SNPs were coded as 0, 1, 2; results were adjusted for matching factor (age of diagnosis); further adjusting for other covariates did not change results substantially

^aCalculated by (10^β–1) × 100%, where β is beta coefficients of linear regressions or the boundaries of their 95% confidence interval

^bP value < 0.05, but none of them are significant after multiple testing adjustment by 2000 permutation

^cThese SNPs were reported previously or in LD with them (rs104875067 in LD with 799039, rs9436302 in LD with rs7602)