Table 1.
Angiogenic molecules
| Groups | Examples of molecules |
|---|---|
| Growth factors | Vascular endothelial growth factor-A (VEGF-A) |
| Platelet-derived growth factor (PDGF) | |
| Acid and Basic Fibroblast growth factor (FGF-1 and -2) | |
| Angiopoietin-1 and -2 (Ang-1 and-2) | |
| Transforming growth factor beta (TGF-β) | |
| Placenta growth factor (PlGF) | |
| Receptor tyrosine kinases | VEGF receptor-1 and -2 (VEGF-1 and -2) |
| PDGF receptors (PDGFRs) | |
| FGF receptors (FGFRs) | |
| Tie-1 and -2 | |
| Adhesion molecules | αvβ3 integrin |
| αvβ3 integrin | |
| VE-cadherin | |
| N-cadherin | |
| immunoglobulin superfamilies (e.g. JAM-C) | |
| Extracellular Matrix (ECM) proteins |
fibronectin |
| Collagens | |
| remodeling and guidance molecules |
Ephrin/Eph |
| Notch/Delta | |
| Robo/Slit | |
| Netrin/UNC-DCC | |
| Semaphoring/plexin ligand/receptor families | |
| Matrix-degrading proteases | Matrix metalloproteinase (e.g. MMP2, and 9) |
| MMP inhibitors (i.e. TIMPs) | |
| Plasminogen activators/inhibitors |
uPA and PAI1 |
| Plasminogen receptors | uPAR |
| Signaling molecules | Raf |
| MAPK | |
| PKA | |
| Rac | |
| PKB | |
| mTOR | |
| Transcription factors | HIF1α |
| NFκB | |
| Transcription inhibitors | Id1 and 2 |
| Homeobox gene products | HoxD3 |
| HJobB3 |