Table 3.
Outcome
|
Locus
|
Test
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Drug | Measure | SNPID | Gene | Chr | Psn (bp) | MAF | MA | n | p value | q value | EFF |
Bupropion | General SE | rs10857636 | WDFY4 | 10 | 49655116 | 0.06 | T | 126 | 1.64 × 10−7 | 0.069 | − |
Bupropion | Sex | rs17150687 | MAGI2 | 7 | 77881227 | 0.02 | C | 128 | 2.76 × 10−6 | 0.097 | − |
Citalopram + Bupropion | Vision/hearing | rs10517287 | 4 | 33301097 | 0.11 | T | 160 | 1.62 × 10−7 | 0.068 | − | |
Citalopram + Bupropion | Vision/hearing | rs17647114 | AGBL1 | 15 | 85237749 | 0.03 | T | 158 | 3.86 × 10−7 | 0.081 | + |
Citalopram + Buspirone | Dizziness | rs16861531 | 2 | 14315503 | 0.03 | G | 152 | 6.90 × 10−7 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs6795349 | CHL1 | 3 | 147477 | 0.03 | G | 149 | 2.28 × 10−6 | 0.080 | + |
Citalopram + Buspirone | Dizziness | rs491376 | 4 | 12725860 | 0.01 | C | 150 | 1.58 × 10−6 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs573332 | 4 | 12731633 | 0.11 | G | 152 | 1.47 × 10−6 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs2163287 | ZDHHC14 | 6 | 157961271 | 0.02 | A | 151 | 2.84 × 10−6 | 0.087 | + |
Citalopram + Buspirone | Dizziness | rs7015622 | 8 | 84066369 | 0.01 | C | 152 | 1.47 × 10−6 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs7016317 | 8 | 84066573 | 0.01 | G | 152 | 1.47 × 10−6 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs10988449 | C9orf50 | 9 | 131410181 | 0.17 | T | 152 | 2.90 × 10−6 | 0.087 | + |
Citalopram + Buspirone | Dizziness | rs8039808 | DTWD1 | 15 | 47727138 | 0.06 | A | 152 | 4.92 × 10−7 | 0.069 | + |
Citalopram + Buspirone | Dizziness | rs10519235 | DTWD1 | 15 | 47733664 | 0.06 | T | 152 | 4.92 × 10−7 | 0.069 | + |
Citalopram + Buspirone | Dizziness | rs10519238 | DTWD1 | 15 | 47756591 | 0.05 | T | 152 | 7.19 × 10−7 | 0.069 | + |
Citalopram + Buspirone | Dizziness | rs2034588 | 16 | 8269328 | 0.02 | G | 152 | 1.64 × 10−6 | 0.069 | + | |
Citalopram + Buspirone | Dizziness | rs12157904 | LGALS2 | 22 | 36311958 | 0.07 | G | 152 | 2.11 × 10−6 | 0.080 | + |
Citalopram + Buspirone | Dizziness | rs16990008 | DMD | 23 | 31925297 | 0.02 | C | 152 | 1.60 × 10−6 | 0.069 | + |
Citalopram + Buspirone | General SE | rs527430 | FOXD2 | 1 | 47691408 | 0.39 | G | 152 | 3.52 × 10−7 | 0.074 | + |
Citalopram + Buspirone | General SE | rs17766217 | POU5F1B | 8 | 128573679 | 0.01 | A | 151 | 2.52 × 10−7 | 0.074 | + |
Sertraline | General SE | rs6724422 | 2 | 67830292 | 0.06 | T | 113 | 3.74 × 10−7 | 0.079 | + | |
Venlafaxine | Dizziness | rs11949289 | 5 | 28375930 | 0.42 | T | 135 | 2.19 × 10−7 | 0.092 | + |
GWAS, Genome-wide association study ; SNP, single nucleotide polymorphism; Chr, chromosome number; Psn, position ; MAF, minor allele frequency ; MA, minor allele; n, sample size; Eff, direction of the effect of minor allele ; SE, side-effect.
Locus information includes Chr and location of SNP (bp, Genome Build 35). For each test, we report n, Eff, where a ‘+’ means a higher factor score, and the p and q values of the test. Shaded rows indicate SNPs in high linkage disequilibrium (LD; r2>0.8) with each other.