Table 1.

Relative risk of Parkinson’s disease according to baseline body mass index (1992) and early adult body mass index (at age 18) and weight change since early adulthood, CPS-II Nutrition Cohort.

Variable	Category of variable distribution					p-trend §	p- heterogeneity ^
	1	2	3	4	5
Body Mass Index * in 1992 #	18.5 -23	23-24.9	25-26.9	27-29.9	>=30
Men
No. cases	62	88	122	95	46
No. PY	104352	167751	201441	185469	106924
RR1	1.0 (Ref)	0.91 (0.66, 1.27)	1.11 (0.82, 1.52)	0.98 (0.71, 1.36)	0.86 (0.58, 1.27)
RR2	1.0 (Ref)	0.93 (0.67, 1.28)	1.17 (0.86, 1.59)	1.06 (0.77, 1.47)	0.98 (0.66, 1.46)	0.80
Women
No. cases	72	52	28	41	33
No. PY	300682	199658	156020	150220	148417
RR1	1.0 (Ref)	1.06 (0.74, 1.52)	0.71 (0.46, 1.11)	1.10 (0.75, 1.61)	0.96 (0.63, 1.45)
RR2	1.0 (Ref)	1.08 (0.76, 1.55)	0.73 (0.47, 1.14)	1.18 (0.80, 1.74)	1.02 (0.66, 1.56)	0.91
Men and Women
RR2		1.00 (0.78, 1.26)	0.95 (0.60, 1.50)	1.11 (0.86, 1.42)	1.00 (0.75, 1.34)	0.79	0.94
Body Mass Index at age 18	<20	20-22.4	22.5-24.9	25-26.9	>=27
Men
No. cases	106	160	90	37	18
No. PY	203070	276690	174326	67257	38329
RR1	1.0 (Ref)	1.13 (0.88, 1.45)	1.05 (0.79, 1.39)	1.16 (0.79, 1.69)	1.04 (0.63, 1.72)
RR2	1.0 (Ref)	1.12 (0.87, 1.43)	1.05 (0.79, 1.39)	1.19 (0.82, 1.74)	1.06 (0.64, 1.74)	0.61
Women
No. cases	99	82	34	9	8
No. PY	429135	359543	120963	29410	28460
RR1	1.0 (Ref)	1.01 (0.75, 1.36)	1.24 (0.83, 1.83)	1.43 (0.72, 2.85)	1.35 (0.65, 2.80)
RR2	1.0 (Ref)	1.02 (0.76, 1.37)	1.23 (0.83, 1.83)	1.43 (0.71, 2.84)	1.36 (0.66, 2.82)	0.17
Men and Women
RR2		1.08 (0.89, 1.30)	1.11 (0.88, 1.40)	1.24 (0.89, 1.73)	1.15 (0.76, 1.73)	0.23	0.40
Weight change between age 18 and 1992# (pounds**)	5lb loss to 5lb gain	5-14.9lb gain	15-24.9lb gain	25-44.9lb gain	>=45lb gain
Men
No. cases	30	49	76	137	105
No. PY	30920	96759	132361	252474	217365
RR1	1.0 (Ref)	0.51 (0.32, 0.81)	0.59 (0.38, 0.89)	0.57 (0.38, 0.84)	0.53 (0.35, 0.80)
RR2	1.0 (Ref)	0.51 (0.32, 0.80)	0.58 (0.37, 0.89)	0.56 (0.37, 0.84)	0.54 (0.35, 0.85)	0.36
Women
No. cases	20	41	43	58	52
No. PY	66150	151042	174495	285362	229905
RR1	1.0 (Ref)	0.92 (0.54, 1.58)	0.83 (0.49, 1.41)	0.68 (0.41, 1.13)	0.74 (0.44, 1.25)
RR2	1.0 (Ref)	0.93 (0.54, 1.60)	0.80 (0.46, 1.40)	0.63 (0.35, 1.11)	0.62 (0.32, 1.21)	0.06
Men and Women
RR2		0.68 (0.38, 1.22)	0.65 (0.46, 0.90)	0.58 (0.42, 0.81)	0.56 (0.39, 0.82)	0.08	0.26

^*Weight (kg)/height(m)²

^#study baseline

^**1 pound = 0.45 kg

¹*adjusted for age in months and smoking in quintiles of pack years

²*adjusted for age in months and smoking in quintiles of pack years, alcohol intake, caffeine intake, calories, dairy intake, physical activity, pesticide exposure and education

^§trend tests conducted in multivariate models

^{^}p-heterogeneity comparing analyses including only men to those including only women