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Effect of DOPA decarboxylase inhibition on TH enzymatic activity. PC12 cells were treated with 0µM (white bars) or 2µM (black bars) MeHg in HBS for 60min in the presence of 10µM NSD-1015. DOPA accumulation was quantified using high-pressure liquid chromatography coupled with electrochemical detection as an index of TH enzymatic activity. * indicates a significant difference between groups (p ≤ 0.05). Values are means ± SEM (n = 4, three replicates per n).
