Fig. 3.
PYY3–36 mediates DON-induced emesis. Experimental design for Y2 receptor antagonist in DON-induced emesis; (B) suppression of DON- and PYY-induced emesis by Y2 receptor antagonists. Emetic events include vomiting (gray) and retching (black) episodes. ND = not detected. Data represent mean ± SEM (n = 4 per group). A one-way ANOVA using Tukey’s test or t-test was used to analyze significant differences between treatments and the respective controls. *p < 0.05 indicates statistically significant differences in emetic events between Y2 receptor antagonist treatment groups and only DON or PYY treatment group. These results and frequency, latency, and duration times are presented in tabular form in Supplementary data.