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. 2013 Mar 1;133(1):186–195. doi: 10.1093/toxsci/kft033

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© The Author 2013. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Fig. 4. — Emesis induction corresponds to elevations in plasma 5-HT. (A) Kinetics of DON-induced plasma 5-HT. Data are the mean ± SEM (n = 4 per group). A two-way ANOVA using Bonferroni t-test was used to assess significant differences in kinetics of 5-HT concentration in plasma. Asterisk indicates statistically significant differences in 5-HT concentration compared with the control at p < 0.05. (B) Relationship between total emetic events and plasma 5-HT at 60min. Cumulative emetic events significantly correlated with plasma 5-HT (Spearman rank-order correlation coefficient = 0.623, p < 0.05).