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. 2013 Mar 1;133(1):186–195. doi: 10.1093/toxsci/kft033

Fig. 5.

Fig. 5.

5-HT mediates DON-induced emesis. (A) Experimental design for 5-HT3 receptor antagonist in DON- and cisplatin-induced emesis; (B) suppression of emesis by 5-HT3 receptor antagonist, granisetron. Emetic events include vomiting (gray) and retching (black) episodes. ND = not detected. Data represent mean ± SEM (n = 4 per group). A one-way ANOVA using Tukey’s test or t-test was used to analyze significant differences between treatments and the respective controls. Asterisk indicates statistically significant differences in emetic events between 5-HT3 receptor antagonist treatment groups and only DON or cisplatin treatment group at p < 0.05. These results and frequency, latency, and duration times are presented in tabular form in Supplementary data.