Fig. 6.

PYY-induced emesis is mediated through 5-HT. (A) Experimental design; (B) suppression of PYY-induced emesis by 5-HT₃ receptor antagonist granisetron. Emetic events include vomiting (gray) and retching (black) episodes. ND = not detected. Data represent mean ± SEM (n = 4 per group). A one-way ANOVA using Tukey’s test or t-test was used to analyze significant differences between treatments and the respective controls. Asterisk indicates statistically significant differences in emetic events between 5-HT₃ receptor antagonist treatment group and only PYY treatment group at p < 0.05. These results and frequency, latency, and duration times are presented in tabular form in Supplementary data.