Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Putative mechanisms for DON-induced emesis. The results presented here suggest that DON could act by inducing PYY release (e.g., L cells) and 5-HT release (e.g., EC cells). These might activate neuropeptide Y2 receptor (NPY2R) and 5-HT3 receptors (5-HT3R), respectively, in the peripheral and central nervous systems, ultimately inducing emesis via the CPG. The potential exists for significant crosstalk (dotted line)ss whereby PYY induces 5-HT release at peripheral and central sites.
