Table 2.
Effect of CRT on adiposity indexes and metabolic profile in 56 survivors of childhood ALL
| |
|
Exposure to CRT |
Effect of CRT |
||||
|---|---|---|---|---|---|---|---|
|
Total |
No |
Yes |
|||||
|
(n = 56) |
(n = 31) |
(n = 25) |
|||||
| Variable | Mean (SD) | Mean (SD) | Mean (SD) | Mean difference (Yes – No) | SE | 95%CI | p |
|
BMI (kg/m2) |
22.7 (4.3) |
21.7 (3.4) |
23.8 (4.9) |
2.13 |
1.12 |
[-0.12; 4.38] |
0.063 |
|
BMI (Z score) |
0.07 (1.17) |
-0.09 (1.20) |
0.27 (1.12) |
0.35 |
0.31 |
[-0.28; 0.98] |
0.266 |
|
FMI (kg/m2) |
6.7 (3.1) |
5.8 (2.8) |
7.7 (3.3) |
2.14 |
0.73 |
[0.67; 3.61] |
0.005 |
|
WC (cm) |
81.1 (12.2) |
78.9 (10.2) |
83.8 (14.1) |
4.80 |
3.25 |
[-1.71; 11.31] |
0.145 |
|
HC (cm) |
94.1 (8.0) |
92.9 (7.6) |
95.5 (8.4) |
2.48 |
2.14 |
[-1.81; 6.78] |
0.251 |
|
Waist-to-hip ratio |
0.86 (0.08) |
0.85 (0.07) |
0.87 (0.10) |
0.02 |
0.02 |
[-0.02; 0.06] |
0.335 |
|
Waist-to-height ratio |
0.50 (0.07) |
0.48 (0.06) |
0.52 (0.09) |
0.04 |
0.02 |
[0.00; 0.08] |
0.065 |
|
TAT (cm3) |
467.0 (279.4) |
374.6 (212.0) |
581.5 (313.1) |
206.91 |
70.38 |
[65.81; 348.01] |
0.005 |
|
VAT (cm3) |
109.6 (64.1) |
88.8 (52.6) |
135.3 (68.7) |
46.42 |
16.21 |
[13.92; 78.91] |
0.006 |
|
SAT (cm3) |
357.4 (231.2) |
285.8 (177.6) |
446.3 (261.2) |
160.49 |
58.80 |
[42.60; 278.38] |
0.009 |
|
VAT/SAT |
0.40 (0.30) |
0.41 (0.34) |
0.37 (0.25) |
-0.07 |
0.07 |
[-0.21; 0.08] |
0.351 |
|
Total cholesterol (mmol/L) |
3.9 (0.9) |
3.6 (0.8) |
4.3 (1.0) |
0.65 |
0.24 |
[0.16; 1.13] |
0.010 |
|
LDL cholesterol (mmol/L) |
2.2 (0.7) |
2.0 (0.6) |
2.6 (0.7) |
0.57 |
0.18 |
[0.21; 0.93] |
0.003 |
|
HDL cholesterol (mmol/L) |
1.2 (0.3) |
1.2 (0.3) |
1.2 (0.3) |
0.02 |
0.08 |
[-0.13; 0.18] |
0.754 |
|
Triglycerides (mmol/L) |
1.0 (0.5) |
1.0 (0.5) |
1.1 (0.5) |
0.14 |
0.14 |
[-0.14; 0.42] |
0.313 |
|
Glucose (mmol/L) |
4.7 (0.4) |
4.6 (0.3) |
4.8 (0.4) |
0.12 |
0.10 |
[-0.08; 0.31] |
0.231 |
|
Insulin (pmol/L) |
65.7 (30.8) |
61.5 (27.5) |
70.8 (34.2) |
9.30 |
8.25 |
[-7.25; 25.84] |
0.265 |
| HOMA1-IR | 2.01 (1.04) | 1.85 (0.92) | 2.20 (1.16) | 0.34 | 0.28 | [-0.21; 0.90] | 0.221 |
CRT Cranial radiotherapy, ALL Acute lymphocytic leukemia, SD Standard deviation, SE Standard error, CI Confidence interval, BMI Body mass index, FMI Fat mass index, WC Waist circumference, HC Hip circumference, TAT Total adipose tissue, VAT Visceral adipose tissue, SAT Subcutaneous adipose tissue, LDL Low-density lipoprotein, HDL High-density lipoprotein, HOMA1-IR Homeostatic model assessment - insulin resistance.