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Inspiratory (A,C) and expiratory (B,D) chest CT images from two subjects with similar percent of lung voxels with attenuation values < −856HU on expiratory CT scans (Exp−856) demonstrate the inability of expiratory image analysis alone to distinguish gas trapping due to emphysema from gas trapping due to small airway disease. Subject 1: Exp−856 = 38.5%, percent emphysema (Insp−950) = 23.1%. Subject 2: Exp−856 = 37.1%, Insp−950 = 6.9%.
