Table 1.
Data Sources
| ID | Data source | Experimental method | Source | Total Genes | Long list | Medium list | Short list | Score |
|---|---|---|---|---|---|---|---|---|
| DS1 | In vitro | functional studies, heterologous expression, inhibitors, in situ hybridization | Pubmed | 181 | 181 | 181 | 85 | 1.0 |
| DS2 | Knockout | gene knockout in mouse models | MGI | 88 | 88 | 88 | 74 | 1.0 |
| DS3 | Disease | identification of genes involved in human disease with olfactory phenotype | Pubmed OMIM | 60 | 60 | 60 | 28 | 1.0 |
| DS4 | Ciliome | proteome analysis of rat OSN cilia | [Mayer et al., 2009] | 377 | 329 | 58 | 24 | 0–1.0 |
| DS5 | OSN microarray | genes identified in mouse OSN | [Sammeta et al., 2007] | 11,596 | 250 | 66 | 17 | 0–1.0 |
| DS6 | OE NGS mouse | RNA-seq of mouse OE | our experimental data | 16,647 | 250 | 141 | 57 | 0–1.0 |
| DS7 | OSN NGS | RNA-seq of mouse single OSNs | our experimental data | 1,000 | 250 | 85 | 32 | 0–1.0 |
| DS8 | OE NGS human | RNA-seq of human OE | our experimental data | 16,647 | 250 | 49 | 16 | 0–1.0 |
| DS9 | Bulb NGS | RNA-seq of mouse olfactory bulb | our experimental data | 16,647 | 250 | 86 | 29 | 0–1.0 |
| DS10 | Linkage | Whole genome linkage analysis of anosmic and hyposmic individuals | [Gerber et al., 2011; Ghadami et al., 2004; Pinto et al., 2008; Sobin et al., 2006] | 596 | 56 | 56 | 8 | 0.5 |
| DS11 | GeneCards | Computerized curation of genes, excluding genes present in DS1 | GeneCards | 260 | 175 | 36 | 8 | 0.5 |
| Total | 1,680 | 450 | 136 |
MGI, Mouse Genome Informatics; NGS, next generation sequencing; OE, olfactory epithelium; OMIM, Online Mendelian Inheritance in Man; OSN, olfactory sensory neuron; RNA-seq, next-generation transcriptome sequencing.