Table 2.
Rawa Scores Obtained in DS-CPT by Carriers of the Different Genotypes of Candidate Polymorphisms of NR4A2b
| Whole Schizophrenic Group (n = 188)c | Only Men Schizophrenic Group (n = 134)d | |||||
| Hits | Reaction Time | Sensibility a | Hits | Reaction Time | Sensibility a | |
| Block 1 | ||||||
| rs1150143 | CC+CG: 0.85 ± 0.12; GG: 0.78 ± 0.23 | CC+CG: 0.85 ± 0.11; GG: 0.72 ± 0.28 | ||||
| rs1150144 | AA+AG: 24.5 ± 10.4; GG: 16.5 ± 9.3 | AA+AG: 0.85 ± 0.12; GG: 0.73 ± 0.26 | AA+AG: 24 ± 10.6; GG: 16.3 ± 8.6 | AA+AG: 0.85 ± 0.11; GG: 0.69 ± 0.30 | ||
| rs834830 | AA: 0.85 ± 0.11; GG: 0.66 ± 0.3 | AA+AG: 0.85 ± 0.12; GG: 0.6 ± 0.31 | ||||
| rs1466408 | ||||||
| rs707132 | ||||||
| Block 2 | ||||||
| rs1150143 | CC+CG: 25.8 ± 9.3; GG: 15.9 ± 11.3 | CC+CG: 0.86 ± 0.13; GG: 0.76 ± 0.16 | CC+CG: 25.3 ± 9.1; GG: 13.2 ± 9.6 | CC+CG: 0.86 ± 0.11; GG: 0.70 ± 0.17 | ||
| rs1150144 | AA+AG: 25.8 ± 9.3; GG: 13.3 ± 10.9 | AA+AG: 0.55 ± 0.09; GG: 0.62 ± 0.15 | AA+AG: 0.86 ± 0.12; GG: 0.72 ± 0.17 | AA+AG: 25.3 ± 9.2; GG: 12.8 ± 8.3 | AA+AG: 0.86 ± 0.12; GG: 0.69 ± 0.17 | |
| rs834830 | AA+AG: 25.4 ± 9.6; GG: 12.2 ± 10.4 | AA+AG: 0.85 ± 0.12; GG: 0.7 ± 0.2 | AA+AG: 24.9 ± 9.4; GG: 13.5 ± 11.5 | AA+AG: 0.85 ± 0.12; GG: 0.7 ± 0.23 | ||
| rs1466408 | ||||||
| rs707132 | AA+AG: 25.5 ± 9.7; GG: 23.2 ± 9.9 | AA+AG: 25 ± 9.5; GG: 22.1 ± 9.7 | AA+AG: 0.85 ± 0.1; GG: 0.81 ± 0.14 | |||
| Block 3 | ||||||
| rs1150143 | CC+CG: 25.5 ± 9.5; GG: 19.4 ± 12 | CC+CG: 0.54 ± 0.09; GG: 0.61 ± 0.1 | CC+CG: 0.86 ± 0.1; GG: 0.78 ± 0.2 | CC+CG: 25 ± 9.5; GG: 16.1 ± 11.8 | CC+CG: 0.55 ± 0.09; GG: 0.62 ± 0.10 | CC+CG: 0.86 ± 0.10; GG: 0.70 ± 0.23 |
| rs1150144 | AA+AG: 25.7± 9.4; GG: 14.2 ± 9.7 | AA+AG: 0.55 ± 0.09; GG: 0.63 ± 0.13 | AA+AG: 0.86 ± 0.12; GG: 0.72 ± 0.2 | AA+AG: 25.2 ± 9.4; GG: 12.6 ± 9.2 | AA+AG: 0.55 ± 0.09; GG: 0.63 ± 0.11 | AA+AG: 0.86 ± 0.11; GG: 0.67 ± 0.20 |
| rs834830 | AA+AG: 25.3 ± 9.6; GG: 13.4 ± 9.8 | AA+AG: 0.55 ± 0.09; GG: 0.64 ± 0.11 | AA+AG: 0.86 ± 0.11; GG: 0.64 ± 0.3 | AA+AG: 24.8 ± 9.6; GG: 10.5 ± 8.5 | AA+AG: 0.55 ± 0.09; GG: 0.65 ± 0.13 | AA+AG: 0.86 ± 0.11; GG: 0.58 ± 0.3 |
| rs1466408 | ||||||
| rs707132 | AA+AG: 25.6 ± 9.4; GG: 22.4 ± 10.9 | AA+AG: 0.86 ± 0.11; GG: 0.81 ± 0.16 | AA+AG: 25.1 ± 9.3; GG: 20.7 ± 11.6 | AA+AG: 0.86 ± 0.1; GG: 0.8 ± 0.17 | ||
Note: CPT-DS, Continuous Performance Test—Degraded Stimulus version.
a
Scores obtained directly from the program, before adjustment for age, sex, years of education, and IQ.
b
Only significative comparisons shown.
c
Number of genotype carriers: rs1150143: CC+CG: 173, GG: 15; rs1150144: AA+AG: 177, GG: 11; rs834830: AA+AG: 183, GG: 5; rs1466408: AA+AT: 1, TT: 187; rs707132: AA+AG: 140, GG: 48.
d
Number of genotype carriers: rs1150143: CC+CG: 125, GG: 9; rs1150144: AA+AG: 126, GG: 8; rs834830: AA+AG: 130, GG: 4; rs1466408: AA+AT: 1, TT: 133; rs707132: AA+AG: 104, GG: 30.