Table 3.
Single Antipsychotic Drug | Combined With Clozapine | Combined With Nonclozapine Antipsychotics | ||||
Adjusted Risk Ratioa | 95% CI | Adjusted Risk Ratioa | 95% CI | Adjusted Risk Ratioa | 95% CI | |
Clozapine | 2.01** | 1.54 –2.61 | — | — | 4.78** | 3.68–6.23 |
Olanzapine | 0.73 | 0.51–1.06 | 22.40** | 9.43–53.18 | 2.33** | 1.71–3.18 |
Quetiapine | 0.86 | 0.61–1.23 | 14.76** | 6.44–33.84 | 1.87** | 1.37–2.56 |
Zotepine | 0.97 | 0.65–1.47 | 4.80** | 2.17–10.64 | 1.57 | 1.09–2.27 |
Risperidone | 0.65** | 0.53–0.80 | 7.49** | 4.47–12.56 | 2.41** | 1.93–3.00 |
Amisulpride | 0.51 | 0.27–0.98 | 21.44** | 4.49–102.30 | 1.36 | 0.80–2.29 |
Adjusted for Charlson comorbidity index at the first admission, and the following variables within 180 d before the index date, including the number of psychiatric hospital admissions, physical illnesses, and concomitant medications (listed in table 1)
*P < .01, **P < .001.