Table 2.

Brain Regions Whose Activity Predicted Empathic Accuracy in Healthy Subjects and Patients With Schizophrenia^a

		Talairach Coordinates
Brain Region	H	x	y	z	t value	Cluster Size
Controls
Posterior cingulate (BA 23)	L	−1	−27	25	4.83	1082b
Cingulate/precuneus (BA 31)	R	−3	−38	34	3.82	1082b
Middle occipital gyrus	R	29	−82	−3	4.88	178
Putamen/caudate	R	15	12	−7	4.49	81
Middle frontal gyrus (BA 8/9)	R	41	24	39	4.46	402
Parahippocampal gyrus (BA 30)	R	12	−46	4	4.24	113
Inferior frontal gyrus (BA 46/13)	R	40	24	9	4.34	212
Precuneus (BA 7/31)	L	−11	−61	31	4.37	591
Inferior parietal lobe (BA 39)	R	47	−63	36	4.08	531
Inferior parietal lobe (BA 40)	L	−48	−46	38	4.04	179
Medial frontal gyrus (BA 9/10)	R	11	30	31	3.03	82
Patients
Middle frontal gyrus (BA 9)	R	48	10	27	4.71	77
Superior frontal gyrus (BA 10)	R	37	54	24	4.82	61
Middle frontal gyrus (BA 46)	R	53	38	21	4.91	62
Lingual gyrus (BA 18)	R	2	−76	0	4.08	82
Middle occipital gyrus (BA 18)	R	29	−82	−3	4.30	218
Cuneus (BA 18)	L	−24	−77	17	4.29	71
Anterior cingulate (BA 32)	R	12	25	37	3.93	60
Middle temporal gyrus (BA 39)	R	53	−68	15	3.42	65
Controls > Patients
Precuneus (BA 31)	L	−5	−65	25	4.22	77
Middle frontal gyrus (BA 8/9)	L	−23	37	38	3.33	92
Thalamus	B	6	−14	15	3.23	97
Patients > Controls
No significant activation

Note: L, Left; R, Right; B, Bilateral; H, Hemisphere; BA, Brodmann’s Area.

^aThe cluster size represents the number of voxels. Talairach coordinates represent the peak voxel of each cluster, where x, y, and z indicate the distance measured in millimeters from the anterior commissure in the sagittal, coronal, and horizontal planes, respectively. All clusters of activation reported in table 2 were significant at P < .01, uncorrected for multiple comparisons, with a minimum cluster size of 53 contiguous voxels, corresponding to a false-positive discovery rate of <5% across the whole brain as estimated by Monte Carlo simulation.

^bThese peaks belong to the same cluster of activation.