Table 2.
Characteristics of Subjects Stratified by Dopamine D2 Occupancy
| Characteristics | Low (n = 102) | Slightly Low (n = 102) | Slightly High (n = 103) | High (n = 103) |
| D2 occupancy, %, range (mean ± SD) | 15.5–62.7 (49.0 ± 11.4) | 62.7–71.8 (67.6 ± 2.6) | 71.9–77.2 (74.4 ± 1.6) | 77.2–85.8 (80.1 ± 1.9) |
| Age, years, mean ± SD (range)a | 39.2 ± 10.6 (20–62) | 39.8 ± 10.0 (20–62) | 41.5 ± 9.4 (21–59) | 43.2 ± 10.9 (18–62) |
| Male, n (%) | 78 (76.5) | 77 (75.5) | 79 (76.7) | 69 (67.0) |
| Duration of education, years, mean ± SD (range) | 12.2 ± 2.4 (3–21) | 12.2 ± 1.8 (6–18) | 12.4 ± 1.8 (7–21) | 12.3 ± 1.9 (3–18) |
| Duration of treatment, years, mean ± SD (range) | 14.8 ± 10.0 (0–40) | 16.0 ± 11.2 (0–39) | 17.9 ± 11.7 (0–56) | 17.3 ± 10.4 (0–42) |
| Antipsychoticsb | ||||
| Risperidone, n (%) | 16 (15.7) | 42 (41.2) | 53 (51.5) | 39 (37.9) |
| Olanzapine, n (%) | 20 (19.6) | 50 (49.0) | 50 (48.5) | 64 (62.1) |
| Ziprasidone, n (%) | 66 (64.7) | 10 (9.8) | 0 (0) | 0 (0) |
| Use of anticholinergics, n (%) | 14 (13.7) | 16 (15.7) | 17 (16.5) | 22 (21.4) |
| PANSS total score, mean ± SD (range) | 68.0 ± 18.8 (32–108) | 68.7 ± 17.3 (32–113) | 71.7 ± 18.3 (34–131) | 71.1 ± 18.6 (33–120) |
| PANSS positive score, mean ± SD (range) | 16.1 ± 5.9 (7–33) | 16.4 ± 5.4 (7–31) | 16.8 ± 5.5 (7–35) | 17.1 ± 5.6 (7–31) |
| PANSS negative score, mean ± SD (range) | 18.4 ± 6.7 (7–36) | 18.2 ± 6.0 (8–35) | 19.7 ± 6.3 (7–38) | 19.7 ± 6.8 (7–38) |
| PANSS general score, mean ± SD (range) | 33.6 ± 9.7 (16–56) | 34.0 ± 9.2 (16–57) | 35.1 ± 9.4 (18–58) | 34.3 ± 9.3 (16–62) |
| SAS mean score, mean ± SD (range)c | 0.16 ± 0.26 (0–1.5) | 0.13 ± 0.19 (0–0.8) | 0.25 ± 0.34 (0–1.83) | 0.22 ± 0.31 (0–1.5) |
Note: Abbreviations are explained in the first footnote to table 1. No statistically significant differences were found in any of the other variables.
a
F 3, 406 = 3.15, P = .03 by the one-way ANOVA; no further statically significant difference was found by the Turkey-Kramer HSD (honestly significant difference).
b
χ2 6 = 200.8, P < .001.
c
F 3, 406 = 3.58, P = .01 by the one-way ANOVA; no further statically significant difference was found by the Turkey-Kramer HSD.