Table 1.
Overview of treatment response and significant changes in hypoxia and proliferation after treatment with C225 and/or radiotherapy
| Model | Response to treatment | Changes in hypoxia | Changes in proliferation |
|---|---|---|---|
| SCCNij202 | Sensitive to C225 | Decrease in hypoxia by C225 | Decrease in proliferation by C225 |
| Radioresistant | No effect of RT | No effect of RT | |
| No synergism C225+RT | Decrease in hypoxia by C225+RT | Trend towards decreased proliferation by C225+RT | |
|
| |||
| SCCNij167 | Resistant to C225 | Decrease in hypoxia by C225 | No effect of C225 |
| Intermediate radioresistant | No effect of RT | No effect of RT | |
| No synergism C225+RT | No effect of C225+RT | No effect of C225+RT | |
|
| |||
| SCCNij153 | Resistant to C225 | No effect of C225 | No effect of C225 |
| Radiosensitive | No effect of RT | Increase in proliferation by RT | |
| No synergism C225+RT | No effect of C225+RT | Increase in proliferation by C225+RT | |
|
| |||
| SCCNij185 | Resistant to C225 | No effect of C225 | No effect of C225 |
| Radiosensitive | No effect of RT | No effect of RT | |
| Synergism C225+RT | No effect of C225+RT | Decrease in proliferation by C225+RT | |
RT: radiotherapy, C225: Cetuximab