Table 2.
Body composition and plasma markers in young and older adult rats
| Variable | Young | Older | P value |
|---|---|---|---|
| Body weight, g | 363.2 ± 12.5 | 756.0 ± 42.6 | <0.0001 |
| Body fat, % | 10.4 ± 0.9 | 34.5 ± 3.1 | <0.0001 |
| Epididymal fat weight, g | 2.0 ± 0.2 | 10.6 ± 1.0 | <0.0001 |
| Epididymal fat weight/body weight | 0.028 ± 0.002 | 0.045 ± 0.002 | <0.0001 |
| Epididymal fat weight, g/tibia length, mm | 0.051 ± 0.005 | 0.228 ± 0.021 | <0.0001 |
| Total cholesterol, mg/dl | 58.7 ± 6.3 | 112.2 ± 7.5 | 0.0003 |
| LDL, mg/dl | 22.3 ± 2.6 | 45.5 | 0.006 |
| HDL, mg/dl | 23.3 ± 1.9 | 32.2 ± 1.2 | 0.003 |
| LDL/HDL | 0.9 ± 0.1 | 1.4 ± 0.2 | 0.035 |
| Triglycerides, mg/dl | 65.3 ± 16.2 | 172.3 ± 27.2 | 0.007 |
| NEFA, mmol/l | 0.64 ± 0.1 | 0.95 ± 0.1 | 0.049 |
| Insulin, ng/ml | 2.4 ± 0.2 | 4.8 ± 0.1 | <0.0001 |
| Glucose, mg/dl | 163.3 ± 9.8 | 146.8 ± 6.0 | 0.182 |
| HOMA-IR index | 0.9 ± 0.1 | 1.7 ± 0.1 | 0.001 |
| Leptin, pg/ml | 7038 ± 2101 | 33279 ± 5280 | 0.0009 |
| TNF-α, pg/ml | 0.9 ± 0.3 | 1.4 ± 0.6 | 0.409 |
| MCP-1, pg/ml | 21.2 ± 2.5 | 32.7 ± 4.0 | 0.042 |
| IL-6, pg/ml | 27.0 ± 7.2 | 37.8 ± 8.6 | 0.359 |
Values are expressed as means ± SE.
LDL, low-density lipoprotein; HDL, high-density lipoprotein; NEFA, nonesterified fatty acids; HOMA-IR, homeostasis model assessment of insulin resistance; TNF-α, tumor necrosis factor-alpha; MCP-1, monocyte chemotactic protein-1; IL-6, interleukin 6.