Fig. 6.

Dose-response effects of intra-arterial endothelin on femoral artery vascular resistance in male sheep exposed antenatally to betamethasone or vehicle. In each panel, the effects of ET-1 are shown along side endothelin plus niacinamide and ET-1 plus dantrolene. The dantrolene and niacinamide infusions were administered for 1 h prior and during the 8 doses of ET-1. Statistical significance for each plot in each panel is indicated by *P < 0.05 for ET-1 dose effect by ANOVA. No significant effects of either niacinamide or dantrolene were observed in either group.