Fig. 2.

QX-314-mediated current in native TRPV1 channels in dorsal root ganglion (DRG) neurons. A: capsaicin-activated current in a DRG neuron with 10 mM external QX-314 vs. 143 mM internal Cs⁺. Solutions as in Fig. 1A. B: capsaicin-activated current in a DRG neuron with 10 mM external QX-314 vs. 135 mM internal NMDG⁺. Solutions as in Fig. 1C. Current-voltage currents were generated using ramp commands as in Fig. 1, subtracting current before and after application of 5 μM capsaicin.