Table 1.
Catecholamine Receptor Expression and Function in Cultured Neuronsa
| Cultured Neuron Origin | Catecholamine Receptor | Receptor Expression | CREB Phosphorylation |
|---|---|---|---|
| Dorsal striatum (caudate/putamen) | D1DAR | M: 1.00 ± 0.02b | M, Veh: 593 ± 115b |
| F: 1.23 ± 0.15b | M, 6-C: 1704 ± 136c | ||
| F, Veh: 568 ± 83b | |||
| F, 6-C: 1454 ± 135c | |||
| Dorsal striatum (caudate/putamen) | D2DAR | M: 1.00 ± 0.08b | Not measured |
| F: 0.98 ± 0.13b | |||
| Hippocampus | β1AR | M: 1.00 ± 0.06b | M, Veh: 1192 ± 97b |
| F: 1.01 ± 0.04b | M, ISO: 2337 ± 173c | ||
| F, Veh: 1210 ± 48b | |||
| F, ISO: 2206 ± 178c | |||
| Hippocampus | β2AR | M: 1.04 ± 0.03b | Not measured |
| F: 1.20 ± 0.15b | |||
| Hippocampus | D2DAR | M: 1.00 ± 0.08b | Not measured |
| F: 0.97 ± 0.13b |
Abbreviations: β1AR, β1-adrenergic receptor; β2AR, β2-adrenergic receptor; 6-C, 6-chloro PB; D1DAR, D1-dopamine receptor; D2DAR, D2-dopamine receptor; F, female; M, male; Veh, vehicle.
a
Values are mean ± SEM. Catecholamine receptor expression values are relative gene expression normalized to males and are unitless. CREB phosphorylation values are fluorescence intensity. 6-Chloro PB is a D1-dopamine receptor agonist; ISO is a β-adrenergic receptor agonist.
b,c
Differences in significance are indicated by superscript letters; no sex differences were detected.