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Paxilline blocks the sustained current in SHCs. A: outward currents from holding potential of −49 mV are sustained. B: currents are attenuated by 1 μM paxilline, which at this concentration specifically blocks BK Ca2+-activated K+ channels. C: current-voltage relationships from records for control (A) and with paxilline (B). D: current-clamp responses with and without 1 μM paxilline, which abolishes ringing and increases the input resistance.
