Table 5.

Haplotypes within HTR3A Associated with Three ND Measures in Pooled Sample

rs1150226-.... -rs2276302						SQ				HSI				FTND
8	9	10	11	12	Freq	No. of families	Z score	P haplotype	P global	No. of families	Z score	P haplotype	P global	No. of families	Z score	P haplotype	P global
G	C	C	T	A	0.408	182	1.823	0.068^d		200	1.853	0.064^d		202	2.209	0.027^d
A	T	C	A	G	0.187	41	-1.153	0.249^r		42	-1.008	0.314^r		43	-0.907	0.365^r
G	T	C	A	G	0.142	20	-1.420	0.156^r	0.080^d	22	-1.372	0.170^r	0.113^a	180	1.631	0.103^d	0.049^d
G	C	C	A	A	0.075	87	-0.817	0.414^a		93	-1.164	0.244^a		99	-1.262	0.207^a
G	C	C	A	G	0.060	73	0.572	0.568^a		85	0.675	0.500^a		98	0.650	0.516^a

rs10160548- .... -rs1176713				SQ				HSI				FTND
13	14	15	Freq	No. of families	Z score	P haplotype	P global	No. of families	Z score	P haplotype	P global	No. of families	Z score	P haplotype	P global
T	G	A	0.390	231	1.464	0.143^a	0.011^a	199	1.386	0.166^d	0.028^a	208	1.235	0.217^d	0.023^a
G	G	A	0.318	219	1.411	0.158^a		190	2.240	0.025^a		201	2.244	0.025^a
G	A	G	0.141	154	-0.637	0.524^a		106	-1.313	0.189^a		109	-1.108	0.268^a
G	G	G	0.135	22	-2.377	0.017^r		23	-2.310	0.021^r		167	-2.190	0.029^a

Notes: 1) Only major haplotypes with a frequency of >5% are shown; those with a P value <0.05 are given in bold. 2) Superscripts indicate genetic model used in the analysis: 3) ND measures were corrected for age, sex, and ethnicity.

additive

dominant

recessive.