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Schematic representation of the novel NRP2-α6β1-FAK-RAS-GLI1 axis involved in the regulation of tumour initiating cells in breast cancer. The pathway is activated by NRP2 and α6β1 integrin, which in turn induces FAK/Ras pathway leading to the activation of GLI1 and the consequent increase in NRP2 and BMI-1 expression.
