Figure 1.

Middle-aged p110α^D933A/WT male mice are resistant to age-related fat accumulation and display better glucose homeostasis than WT littermates. Parameters were assessed in approximately 500-day-old male mice. Bars represent mean ± standard error. Statistical comparisons were performed with Student's t-test.

A. Body weight (n = 17 per genotype).

B. Epididymal fat pad weight (n = 3 per genotype).

C. Cumulative food intake over 10 days (left panel), expressed per kg of body weight (right panel; n = 9 p110α^D933A/WT–7 WT).

D. Fasting plasma insulin (n = 5 per genotype).

E. Fasting plasma glucose (n = 11 p110α^D933A/WT–12 WT).

F. Glucose tolerance injected intraperitoneally with 2 g glucose/kg body weight (n = 11 p110α^WT/D933A–12 WT).