Figure 4.

Extension of lifespan of male p110α^D933A/WT mice.

A. Survival curves of p110α^D933A/WT mice. Cohorts of p110α^D933A/WT (n = 26) and WT (n = 42) male mice were monitored from birth to death as described in Materials and Methods. Median lifespan was 818 days (p110α^WT/D933A) versus 799 days (WT). The difference between the curves is marginally statistically significant (log-rank test, p = 0.0545, x² = 3.697).

B. Survival analysis limited to mice surviving to 500 days of age (n = 21 for p110α^WT/D933A and n = 40 for WT). Median life span was 852 days (p110α^WT/D933A) versus 805 days (WT). The difference between the curves is statistically significant (log-rank test, p = 0.0094, x² = 6.739).