Figure 6.

Blocking IL-10R leads to the absence of Mikulicz cells.

A. Percentage of inflammatory monocytes in lungs of BALB/c mice treated with IL-10R blocking antibody or control IgG 4 days post-infection with K. rhinoscleromatis. (***p < 0.001). Data are representative of 10 mice from two independent experiments.

B. Comparison of number of Mikulicz cells in tissue sections between BALB/c WT mice and mice injected with IL10R neutralizing antibody. Data are mean ± SEM. n = 39 and 40. ***p < 0.0001.

C. Histology, representative examples of lungs in mice injected with IL-10R neutralizing antibody or control IgG. Arrow points to a rare Mikulicz cell observed. Scale bars: 100 µm.