Table 4.
Cox proportional hazard models of factors predictive of blast transformation in patients with PMF
| Cox model |
P | |
|---|---|---|
| HR (95% CI) | ||
| Univariable analysis | ||
| Age > 50 y | 4.92 (2.5-9.7) | < .001 |
| Female sex | 1.49 (0.79-2.8) | .21 |
| WBC count | 1.1 (0.96-1.07) | .48 |
| Hemoglobin | 0.86 (0.79-0.93) | < .001 |
| PB blasts > 1% | 1.12 (0.95-1.33) | .17 |
| Serum cholesterol level | 0.97 (0.96-0.99) | .002 |
| IPSS score | 2.69 (2.09-3.47) | < .001 |
| CD34+ cell in PB | 1..02 (1.01-1.02) | < .001 |
| JAK2V617F homozygous genotype | 3.15 (1.58-6.26) | .001 |
| G/G genotype of the GR A3669G variant in JAK2 V617F–mutated patients | 4.75 (2.06-10.9) | < .001 |
| Multivariable analysis (in JAK2 V617F–mutated patients) | ||
| Age > 50 y | 4.16 (1.58-6.26) | < .001 |
| JAK2V617F homozygous genotype | 2.28 (1.12-4.61) | .021 |
| G/G genotype of the GR A3669G variant | 3.33 (1.40-7.89) | .006 |