Figure 1.
Composition of the tumor microenvironment from a mouse melanoma tumor. C57BL/6 mice were injected subcutaneously with 0.75 × 106 B16.F10 melanoma cells. After 14 days tumors were excised and sections stained with the Hematoxylin/Eosin method. (A) 40× Magnification. Blood vessel with red blood cells (red circular cells) is shown. (B) Detail of the blood vessel depicted in (A) with the indication of the various functional structures linking blood vessel and tumor milieu. Yellow arrows, tumor-infiltrating leukocytes; red arrows, red blood cells; black arrows, melanoma cells.