Table 1.
Main structural and cellular components of the tumor microenvironment.
| Macrostructure | Subcomponents |
|---|---|
| RESIDENT | |
| Blood vessels | Endothelial cells |
| Pericytes | |
| Mesenchyma | Mesenchymal stem cells |
| Mesenchymal cancer cells | |
| Fibroblasts | |
| Cancer-associated fibroblasts | |
| Cancer stem cells | |
| Structural components | Adhesion molecules |
| Cytokines | |
| Chemokines | |
| NON-RESIDENT | |
| Infiltrating leukocytes | T lymphocytes |
| B lymphocytes | |
| Monocytes | |
| Dendritic cells | |
| Macrophages | |
| Myeloid suppressor cells | |
| Natural killer cells | |
| Circulating stem cells | |
| Tumor-derived cells | Metastatic cancer cells |
| Cancer stem cells | |