Figure 2. Evolutionary relationships of exogenous and endogenous totiviruses showing the derived and non-monophyletic positions of viruses and paleoviruses from CTG yeast (in red).

Asterisks indicate paleoviral sequences. Numbers are support values (SH-like approximate likelihood tests estimated in PhyML 3.0). The phylograms are estimated using the maximum likelihood (ML) optimality criterion from alignments of predicted amino acid residues of (A) the RNA dependent RNA polymerase gene (RdRp) and (B) the capsid gene. Shaded boxes indicate the two major clades of totivirus-like sequences. Genbank Accession numbers are provided in parentheses.