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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: Mol Cell. 2013 Mar 7;50(1):56–66. doi: 10.1016/j.molcel.2013.02.001

Figure 6. A model for SRSF1’s Role in the Ribosomal-stress Pathway and Oncogene-Induced Senescence.

Figure 6

We have identified SRSF1 as a critical component of the RP-MDM2 complex, which is formed in response to induction of ribosomal stress. Sequestration of the E3 ligase MDM2 in this complex results in decreased ubiquitylation and increased stability of the tumor-supressor p53 protein. Moreover, we have identified and characterized an anti-tumorigenic response that primary cells mount in response to overexpression of the SRSF1 oncoprotein, which triggers the formation of a nuclear ternary SRSF1-RPL5-MDM2 complex, leading to activation of the p53-mediated tumor-suppressive pathway and OIS.