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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Mar 21;78(1):138–151. doi: 10.1016/j.neuron.2013.01.030

Figure 4. Ablation of CGRPα DRG neurons eliminates heat sensitivity and hypersensitivity but does not affect mechanical sensitivity in models of inflammatory pain and neuropathic pain.

Figure 4

(A–F) CFA inflammatory pain model in male and female CGRPα-DTR+/− mice. CFA injected into one hindpaw. Contralateral hindpaw not injected and served as a control. (A,B) Plasma extravasation, (C,D) hindpaw radiant heat sensitivity, (E,F) mechanical sensitivity. Arrows indicate when mice were injected i.p. with saline or DTX (S/D). (G,H) SNI model of neuropathic pain in male mice. (G) Heat sensitivity and (H) mechanical sensitivity. n=10 mice/treatment group. Paired t tests were used to compare responses at each time point between saline- and DTX-treated mice, same paw comparisons. Black asterisks relative to Saline Contra paw; gray asterisks relative to DTX Contra; red asterisks relative to DTX CFA. *p<0.05, **p<0.005, ***p<0.0005.