(A–F) CFA inflammatory pain model in male and female CGRPα-DTR+/− mice. CFA injected into one hindpaw. Contralateral hindpaw not injected and served as a control. (A,B) Plasma extravasation, (C,D) hindpaw radiant heat sensitivity, (E,F) mechanical sensitivity. Arrows indicate when mice were injected i.p. with saline or DTX (S/D). (G,H) SNI model of neuropathic pain in male mice. (G) Heat sensitivity and (H) mechanical sensitivity. n=10 mice/treatment group. Paired t tests were used to compare responses at each time point between saline- and DTX-treated mice, same paw comparisons. Black asterisks relative to Saline Contra paw; gray asterisks relative to DTX Contra; red asterisks relative to DTX CFA. *p<0.05, **p<0.005, ***p<0.0005.