Table 2.

Area under the folate concentration-time curve from time 0 (baseline) to week 24 (AUC_{(0–24 weeks)}) for plasma and RBC folate (uncorrected and corrected for baseline folate concentrations) after administration of EE-drospirenone-levomefolate calcium or EE-drospirenone + folic acid for 24 weeks (invasion phase; per protocol set)

	Plasma folate AUC(0–24 weeks) (nmol week/L)		RBC folate AUC(0–24 weeks) (nmol week/L)
	Baseline-uncorrected	Baseline-corrected	Baseline-uncorrected	Baseline-corrected
EE-drsp-levomefolate calcium (n = 75)	1030 (24.0)	640 (29.0)	24,176 (21.8)	10,427 (34.3)
EE-drsp + folic acid (n = 75)	904 (22.3)	561 (32.7)	21,876 (17.7)	8863 (24.6)

Note: Data presented as geometric mean (% geometric coefficient of variation).

Abbreviation: AUC, area under the concentration-time curve; drsp, drospirenone; EE, ethinylestradiol; RBC, red blood cell.