Table 4.

Mean metabolite concentrations in plasma (nmol/L)

	EE-drsp-levomefolate calcium		EE-drsp + folic acid
	THF	5,10-methenyl-THF	THF	5,10-methenyl-THF
Baseline	4.07 ± 0.357 (n = 4)	1.57 ± 0.412 (n = 9)	4.60 ± 0.656 (n = 7)	1.63 ± 0.372 (n = 8)
Week 12	4.98 ± 1.851 (n = 13)	1.76 ± 0.603 (n = 7)	5.28 ± 1.806 (n = 14)	1.45 ± 0.282 (n = 7)
Week 24	5.92 ± 2.318 (n = 23)	1.46 ± 0.238 (n = 12)	5.76 ± 2.835 (n = 19)	1.95 ± 1.166 (n = 12)

Notes: Values are presented as the mean ± standard deviation. Lower level of quantification = THF, between 3.447 and 3.539 nmol/L; 5,10-methenyl-THF, between 1.052 and 1.284 nmol/L.

Abbreviations: drsp, drospirenone; EE, ethinylestradiol; THF, tetrahydrofolate.