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. Author manuscript; available in PMC: 2013 Apr 17.
Published in final edited form as: Cancer Res. 2008 Sep 15;68(18):7638–7649. doi: 10.1158/0008-5472.CAN-07-6614

Figure 4. Ultrasound treatment followed by topical application of siMutB-Raf-nanoliposomal complex inhibits melanocytic lesion development in reconstructed skin.

Figure 4

A. Schematic showing treatment regime. Beginning on d 10 and on alternate days thereafter up to d 20, reconstructed skin was treated with ultrasound for 20 m followed by topical administration of siMutB-Raf-nanoliposomal complex (100 pmoles) or ghost nanoliposomes. B., C. Ultrasound followed by addition of siMutB-Raf-nanoliposomal complex decreases melanocytic lesion development in skin. Reconstructed skin containing UACC 903-GFP or WM35-GFP cells were treated with ultrasound for 20 m followed by topical administration of siMutB-Raf-nanoliposomal complex on alternated days from d 10–20. Skin was harvested on d 21, and average area occupied by GFP-tagged tumors calculated for each group. Ultrasound treatments followed by exposure to ghost nanoliposomes served as a control. Results are mean±SE.