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. Author manuscript; available in PMC: 2014 Apr 5.
Published in final edited form as: Mol Biosyst. 2013 Apr 5;9(4):586–595. doi: 10.1039/c2mb25429h

Figure 1. Schematic diagram shows a GPCR and possible ligand binding sites.

Figure 1

Orthosteric sites are usually at the outer surface of the receptor and sometimes in the extracellular N-terminus region. Allosteric sites are distinct from the orthosteric sites and can be located in any region of the receptor. GPCRs bound to G proteins vs. arrestins show differential signaling behaviors.