Table 1.
Summary of importin αs and karyopherin βs known to be responsible for nuclear transport of homeoproteins
| Homeoprotein | Homeoprotein functions | Karyopherins/importins with a transport role | Sensitivity to LMB |
|---|---|---|---|
| Arx | early development of multiple tissues [94, 138, 139] | importin β1, 9, 13 [22, 73, 95] importin α3, α5 (unpublished observation) |
|
| Brn2 | differentiation of Schwann cells [140] | importin α5 [90] | |
| Caudal | anteroposterior body axis of Drosophila [97, 98] | Dim7 (importin 7) [99] | |
| Cdx2 | pattern formation in the developing embryo [141] | Yes [130] | |
| Exd (Pbx) | embryogenesis [41, 43, 82, 83] | Yes [134] | |
| Hex | embryonic patterning [115] | importin 7 [117] | |
| Nkx 2.2 | early development of multiple tissues [100, 101] | importin β1, 4, 7, 9, 13 (unpublished observation) | |
| Oct 3/4 | differentiation of neuronal cells [142] | importin α1, α3, α5 [90] | |
| Oct6 | differentiation of neuronal cells [143] | importin α3, α5 [90] | Yes [85, 90] |
| Pax6 | development of CNS system and pancreas [104-109] | importin 13 [70] | |
| Pdx1 | pancreatic cell-type maintaining [110-112] | importin β1 [114] | |
| PLC-HDP | ocular development [144, 145] | Yes [64] | |
| prospero | regulation of cell fate [146] | Yes [86, 87] | |
| Yox1p | regulating G1/S transition [91, 92] | importin α [92] |