Figure 1. P. berghei ANKA infection causes accelerated mortality in 5-LO-deficient mice.

C57Bl/6 WT or Alox5 ^−/− (n = 8 mice/group) mice were infected i.p. with P. berghei ANKA strain. Survival (A) and parasitemia (B) were monitored daily. The presence of parasite 18S rRNA in the brains of infected mice was determined by real-time RT-PCR in perfused samples obtained 5 days after infection (C). Data are representative of 5 independent experiments performed with similar results. Statistical analysis of survival studies was determined using Log-rank (Mantel-Cox) method, in panel C, statistical analysis was performed using Mann Whitney test.